Since the discovery of association of FOXO3A gene with longevity in Japanese population by a team of US and Japanese scientists headed by Dr. Bradley Willcox of the Pacific Health Research Institute and the University of Hawaii in Honolulu, such association has been also found in German and French and Italian populations.Published in December issue of Human Molecular Genetics, Dr. Yang Li, Wen-jing Wang and Huiqing Cao from Department of Human Population Genetics, Institute of Molecular Medicine, reported that such correlation also exist among Han Chinese population. In their study, six tagging SNPs from FOXO1A and FOXO3A were selected and genotyped in 1817 centenarians and younger individuals. Two SNPs of FOXO1A were found to be associated with longevity in women (P = 0.01–0.005), while all the three SNPs of FOXO3A were associated with longevity in both genders (P = 0.005–0.001). The study further confirms likely an universal connection between FOXO3A with longevity. In addition, FOXO1A is more closely associated with human female longevity, suggesting that the genetic contribution to longevity trait may be affected by genders.
Since the discovery of association of FOXO3A gene with longevity in Japanese population by a team of US and Japanese scientists headed by Dr. Bradley Willcox of the Pacific Health Research Institute and the University of Hawaii in Honolulu, such association has been also found in German and French and Italian populations.Published in December issue of Human Molecular Genetics, Dr. Yang Li, Wen-jing Wang and Huiqing Cao from Department of Human Population Genetics, Institute of Molecular Medicine, reported that such correlation also exist among Han Chinese population. In their study, six tagging SNPs from FOXO1A and FOXO3A were selected and genotyped in 1817 centenarians and younger individuals. Two SNPs of FOXO1A were found to be associated with longevity in women (P = 0.01–0.005), while all the three SNPs of FOXO3A were associated with longevity in both genders (P = 0.005–0.001). The study further confirms likely an universal connection between FOXO3A with longevity. In addition, FOXO1A is more closely associated with human female longevity, suggesting that the genetic contribution to longevity trait may be affected by genders.
2007